![]() The 3D structured scaffolds and hydrogels alone or combined with bioactive molecules or genes and cells are able to guide the development of functional engineered tissues, and provide mechanical support during in vivo implantation. Read more about how to correctly acknowledge RSC content.During the past two decades, tissue engineering and the regenerative medicine field have invested in the regeneration and reconstruction of pathologically altered tissues, such as cartilage, bone, skin, heart valves, nerves and tendons, and many others. ![]() Permission is not required) please go to the Copyright If you want to reproduce the wholeĪrticle in a third-party commercial publication (excluding your thesis/dissertation for which If you are the author of this article, you do not need to request permission to reproduce figuresĪnd diagrams provided correct acknowledgement is given. Provided correct acknowledgement is given. If you are an author contributing to an RSC publication, you do not need to request permission Please go to the Copyright Clearance Center request page. To request permission to reproduce material from this article in a commercial publication, Provided that the correct acknowledgement is given and it is not used for commercial purposes. This article in other publications, without requesting further permission from the RSC, Li,Ĭreative Commons Attribution-NonCommercial 3.0 Unported Licence. The results gathered in this paper may provide a theoretical basis and data support for fabricating small-diameter porous tissue engineering vascular scaffolds.įabrication of fibrillated and interconnected porous poly(ε-caprolactone) vascular tissue engineering scaffolds by microcellular foaming and polymer leaching HUVECs tend to align along the direction of the pore orientation in the PCL70 scaffold, whereas HUVECs have a higher density and spreading area in the PCL50 scaffold. The PCL70 scaffold has a greater longitudinal tensile strength, longer toe region, and larger cyclical recoverability. Prominent orientated pores are found in the PCL70 scaffold, and a mixed microstructure combining interconnected channels and open cells occurs in PCL50 scaffold. Small-diameter tubular PCL70 and PCL50 porous scaffolds with an average pore size of 48 ± 1.4 μm and 30 ± 1.0 μm respectively, are fabricated successfully. ![]() Moreover, the leaching process had a greater contribution to improve the open-cell content in the PCL50 blend, which has a co-continuous morphology and easily obtained open-cell content of more than 80%. After the leaching process, highly interconnected and fibrillated porous structures are detected in the foamed PCL70 blend with droplet-matrix morphologies. When PEO content increases, the pore size decreases and the pore density increases. The relationship between pore morphology and mechanical properties, and the cytocompatibility, are investigated with respect to the effects of poly(ε-caprolactone)/poly(ethylene oxide) (PCL/PEO) phase morphologies and PEO leaching. This paper provides a method combining eco-friendly supercritical CO 2 microcellular foaming and polymer leaching to fabricate small-diameter vascular tissue engineering scaffolds. ![]()
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